Thr160
WebJan 1, 2006 · The enzymatic activity of the CDK2/Cyclin A complex increases upon the specific phosphorylation of Thr160@CDK2. In the present study, we have performed a comparative molecular dynamics (MD) study of models of the complex CDK2/Cyclin A/Substrate, which differ for the presence or absence of the phosphate group bound to … WebIn an activated CDK2, which is phosphorylated at Thr160, the Val164 residue in the activation loop establishes interactions with surrounding residues and adopts an unusual left-handed conformation in order to create a binding pocket to accommodate a trans-conformation proline.
Thr160
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WebJul 21, 2002 · 1H1P, 1H1Q, 1H1R, 1H1S. PubMed Abstract: Aberrant control of cyclin-dependent kinases (CDKs) is a central feature of the molecular pathology of cancer. … WebApr 10, 2015 · Thr160 of Axin1 is critical for the formation of the Axin1-APC complex. (A) Schematic representations of wild-type Axin1 and Axin1 mutants. (B) Alignment of …
WebHuman and Mouse p-CDK2 (Thr160) Detection Kit C ALSU-PCDK2-A500, ALSU-PCDK2-A10K, ALSU-PCDK2-A50K, ALSU-PCDK2-A-HV Kit Specificity This assay kit contains antibodies which recognize the phospho-Thr160 epitope and a distal epitope on CDK2. The protein detected by this kit corresponds to UniProt ID P24941. WebCDK2 was mutated at Lys33 in the ATP binding site (K33R) or Thr160 (T160A) or when treated with lambda phosphatase. Mass spectrometry based phosphopeptide mapping …
WebThe levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase. WebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
WebJun 26, 2003 · The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, …
WebCDK2 (phospho Thr160) antibody detects CDK2 (phospho Thr160) protein at cytoplasm and nucleus by immunohistochemical analysis. Sample: Paraffin-embedded human colon … black bathroom floor side cabinetWebInvitrogen Anti-Phospho-CDK2 (Thr160) Polyclonal, Catalog # PA5-77906. Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody … gainsby brains gymsharkWebPhospho-CDK2-Thr160 polyclonal antibody (Cyclin-Dependent Kinase 2) binds to endogenous Cyclin-Dependent Kinase 2 at the amino acid region 100-180 only when phosphorylated at Thr160. Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Cdk2/Cdc2 (phospho Thr160) black bathroom floor cabinetsWebHuman and Mouse p-CDK2 (Thr160) Detection Kit C ALSU-PCDK2-A500, ALSU-PCDK2-A10K, ALSU-PCDK2-A50K, ALSU-PCDK2-A-HV Kit Specificity This assay kit contains antibodies … gainsbybrains shred guide pdf freeWebApr 10, 2015 · Consistent with these observations, the Axin1 phosphomimetic mutant lost the ability to reduce β-catenin stability and to repress β-catenin/TCF-dependent transcription. Taken together, our results suggest a novel mechanism of Wnt signaling through the dissociation of the β-catenin destruction complex by Axin1 Thr160 modification. black bathroom floor tiles ukWebApr 10, 2015 · Thr160 of Axin1 is critical for the formation of the Axin1-APC complex. (A) Schematic representations of wild-type Axin1 and Axin1 mutants. (B) Alignment of sequences flanking the Thr160 site in Axin1 proteins from human, mouse and rat. Thr160 (Thr165 in mouse) is indicated in bold. gainsbybrains reviewWebJan 17, 2012 · We demonstrated for the first time that monocillin II could arrest breast cancer cell cycle in G1 phase, which might partially be the result of its inhibition effect on the phosphorylation of the Thr160 residue of cyclin dependent kinase 2 (CDK2), a key enzyme in cell-cycle regulation. black bathroom floor mat