Stathmin-3
WebIntroduction: Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the downstream target of many signal transduction pathways. Several studies then indicated … WebTitle: Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons. Studies suggest that a STAT3-SCLIP …
Stathmin-3
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WebReduced stathmin-2 expression is found in neurons trans-differentiated from patient fibroblasts expressing an ALS-causing TDP-43 mutation, in motor cortex and spinal motor neurons from patients with sporadic ALS and familial ALS with GGGGCC repeat expansion in the C9orf72 gene, and in induced pluripotent stem cell (iPSC)-derived motor neurons de... WebApr 11, 2024 · In neuronal cells that were genome edited to carry an ALS- and FTD-linked TDP43 mutation (TDP43 N352S/N352S), mRNA encoding full-length stathmin 2 was reduced by 50% compared with wild-type cells ...
http://www.neobioscience.com/prod_view.aspx?TypeId=409&Id=2337947&FId=t3:409:3 WebJan 23, 2002 · It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and …
WebMar 26, 2024 · Stathmin-2 is highly regulated by the RNA splicing factor TDP-43 (encoded by Transactive response DNA binding protein-43 kDa, TARDBP) that forms hallmark neuronal protein aggregates in both familial and sporadic ALS (sALS) ( Nguyen et al., 2024 ), and knockdown of TDP-43 was recently shown to significantly reduce STMN2 transcript levels … WebStathmin, a key oncoprotein, was proved to be a new PRL-3 associated protein. Notably, co-immunoprecipitation assays in both endogenous CRC cell lines and CRC tissues indicated …
WebSep 27, 2016 · Knowledge of the molecular mechanisms on malignant tumors is very critical for the development of new treatment strategies like molecularly targeted therapies. In …
WebGene summary (Entrez)i. Useful information about the gene from Entrez. This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a comp lex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation ... kk4e型エステルバンド引締機WebAbstract. Background/Aims: Several recent studies have demonstrated that Stathmin 1expression may be closely associated with prognosis in patients with various types of cancers. In the present study, we conducted a meta-analysis of all available studies in the English literature to assess the prognostic value of Stathmin 1expression in patients with … kj 長袖シャツStathmin-3 is a protein that in humans is encoded by the STMN3 gene. aetb rachimedia.comWebAug 5, 2024 · STMN3 stathmin 3 [ (human)] Gene ID: 50861, updated on 5-Aug-2024 Summary This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. kkbox 退会できない auWebMar 26, 2024 · Additionally, sALS patients and controls exhibited variable expression of Stathmin-2 mRNA according to CA genotype in laser-captured spinal motor neurons. Conclusions: We report a novel non-coding CA repeat in Stathmin-2 which is associated with sALS disease risk and has disease modifying effects. The potential value of this variant … kkbox 無料会員 できることWebMar 17, 2024 · Scientists have found that TDP-43 is essential for proper maturation of the pre-mRNA encoding stathmin-2, a protein necessary for the outgrowth of neurons’ axons during development and regeneration following any injury. In a paper in Science, researchers led by a group at the University of California, San Diego, and including Cathleen Lutz ... kk83 イセキWebJan 18, 2024 · This study established the critical role of TDP-43 in RNA processing within motor neurons and showed that known ALS-associated mutations in TDP-43 dysregulate hundreds of its RNA targets, including stathmin-2. Specifically, TDP-43 depletion in the nucleus leads to aberrant splicing and premature polyadenylation of stathmin-2. kj 菅さん