Phospholipase a2 receptor antibody pla2r
WebFeb 20, 2024 · M-type phospholipase A2 receptor 1 (PLA2R) has been described as a major antigen in iMN, with anti-PLA2R antibodies (Abs) present in ∼70% of incident patients [ 2, 3 ]. The specificity of anti-PLA2R Abs for the diagnosis of iMN, albeit not absolute, is now well established [ 3–5 ]. WebMar 14, 2024 · The discovery of antibodies against M-type phospholipase A2 receptor (PLA2R) situated on the cell surface of human podocytes has been a turning point for the MN field . Until recently, we lacked experimental evidence that PLA2R was indeed the culprit antigen that triggered the disease, mainly because it is not expressed on mouse podocytes.
Phospholipase a2 receptor antibody pla2r
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WebFeb 1, 2024 · The reporting of anti-phospholipase A2 receptor antibody (PLA2RAb) positivity in 70% of patients with primary MN (PMN) in 2009 was a significant advance in the understanding of the disease pathogenicity. What is the antigen? The M-type phospholipase A2 receptor (PLA2R) on the cell surface of podocytes is the target antigen for PLA2RAb. WebAnti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy. As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R. This test can be used to identify …
Webbeck等 首次在成人imn患者血清中检测到抗m型磷脂酶a2受体(pla2r)的自身抗体，并发现抗体滴度与患者蛋白尿的消长相关，提示pla2r可能是imn的重要靶抗原。我们前期已针对血清pla2r抗体进行检测，发现病情缓解的imn患者血清学阳性率明显降低，提示单纯采用血 … Web180 kDa secretory phospholipase A2 receptor antibody; C-type lectin domain family 13 member C antibody; CLEC13C antibody; M type receptor antibody; ... Ramachandran R et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians.
WebAntibodies to the phospholipase A2 receptor (PLA2R) occur in 70% to 80% of patients. Less frequently (in up to 10%), antibodies against thrombospondin type-1 domain-containing … Web因此有学者提出，磷脂酶A2可评估IMN的临床疗效与预后。本文拟对此研究状况做以综述。 一、PLA2R的结构. PLA2R属于甘露糖受体（Mannose Receptor，MR）家族，1989年由Stanescu等[5]首次对其做了报道。迄今为止，共发现了两个亚型的PLA2R——M型和N型[6]。
WebOct 8, 2015 · PLA2R — Phospholipase A2 Receptor Antibodies, Serum View all test information details. 63036 — Phospholipase A2 Receptor (PLA2R) Immunofluorescent …
WebJan 3, 2024 · Phospholipase A2 receptor (PLA2R) is the most common primary target antigen of idiopathic membranous nephropathy (MN) although PLA2R antibodies are also reported to be present in malignancy-associated MN. However, a case of PLA2R-positive MN secondary to PLA2R-positive carcinoma has not been reported. shopkids setWebApr 11, 2024 · Approximately 80% of PMN cases arise due to autoantibodies that recognize the phospholipase A2 receptor (PLA2R) antigen expressed on podocytes. Anti-PLA2R is both a diagnostic and prognostic biomarker, and total aPLA2R antibody level has been shown to be a biomarker for prognosis of outcome in patients with PMN. shopkin animalsWebPhospholipase A2 Receptor (PLA2R) Antibody, IgG with Reflex to Titer 2011828 Copy Utility Click to copy Test Number / Name Choose the Right Test ARUP Consult® assists with … shopkin apps freeWebMar 10, 2024 · The M-type phospholipase A2 receptor (PLA2R) has been identified as the main target antigen in the pathogenesis of iMN . Some evidence suggests that IgG4 anti-PLA2R antibodies can bind MBL to activate the lectin complement pathway . Based on this evidence, we hypothesized that MBL-initiated complement activation is involved in the … shopkimberguns.comWebObjective To explore the value of anti-phospholipase A2 receptor (PLA2R) antibody in the diagnosis and disease activity monitoring of idiopathic membranous nephropathy … shopkimkimble.comWebHave a medical condition that can cause damage to the kidneys including cancer and lupus. Symptoms and Causes What causes membranous nephropathy (MN)? Most cases of MN are now known to be caused by an antibody to a protein on the podocyte called the phospholipase A2 receptor (PLA2R). shopkin accessoriesWebSep 21, 2024 · Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful for affirming the diagnosis of idiopathic membranous nephropathy (IMN). Time-resolved fluoroimmunoassay (TRFIA) is highly sensitive and ... shopkin aqua beads