Nejm hypothermia vs normothermia
WebThe New England Journal of Medicine WebDec 27, 2024 · Explore Cardiac Arrest articles from NEJM Evidence. The Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital (THAPCA-OH) trial (ClinicalTrials.gov number, NCT00878644) compared therapeutic hypothermia (33°C) with therapeutic normothermia (36.8°C) in 295 children suffering from out-of-hospital cardiac …
Nejm hypothermia vs normothermia
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WebJan 29, 2024 · @article{Shrestha2024HypothermiaVN, title={Hypothermia versus normothermia after out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials}, author={Dhan Bahadur Shrestha and Yub Raj Sedhai and Pravash Budhathoki and Suman Gaire and Anurag Adhikari and Ayusha Poudel and … WebJul 22, 2024 · Hypothermia was first introduced in 2002 by two studies, Bernard et al and The Hypothermia After Cardiac Arrest (HACA) trial. 1,2 The latter, although a small trial, showed improved neurologic outcomes at six months when patients were cooled to 32-34 o C. For a long time, a temperature of 33 o C was the widely accepted standard of therapy …
WebJun 17, 2024 · Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. Dankiewicz J for the TTM2 Trial Investigators. ... The HACA trial (n=137) and Bernard trials (n=77) published in NEJM in 2002 reported that therapeutic hypothermia following a VF arrest improved favourable neurological outcome. WebThere were 23 deaths (21%) in the hypothermia group, as compared with 14 deaths (12%) in the normothermia group (relative risk of death with hypothermia therapy, 1.40; 95% CI, 0.90 to 2.27; P=0.06 ...
WebJun 16, 2024 · However, while the target temperature for TTM could be 33ºC, 36ºC, or ≤37.5ºC, the relatively high survival rate found in the study (all cause mortality was 50% and 48% at 6 months in the hypothermia and normothermia groups, respectively) reinforces the need to ensure that each element of the TTM protocol is followed. WebJun 15, 2012 · Past studies of therapeutic hypothermia have been criticized because control patients were hyperthermic as well as normothermic. In a retrospective. NEJM Journal Watch reviews over 250 scientific and medical journals to present important clinical research findings and insightful commentary.
WebJun 17, 2024 · In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not lead to a lower incidence of death by 6 months than targeted normothermia. (Funded by the Swedish Research Council and others; TTM2 ClinicalTrials.gov number, NCT02908308.).
WebJun 29, 2024 · Josef Dankiewicz, Tobias Cronberg, Gisela Lilja et el published a trial of normothermia vs hypothermia in out of hospital cardiac arrest in NEJM. BACKGROUND. Targeted temperature management (TTM, therapeutic hypothermia) after cardiac arrest first came to use in clinical setting since the publication of two landmark articles in … foreign assistance act of 1961 section 632 bWebJun 17, 2024 · NEJM Evidence NEW! A digital journal for innovative original research and fresh, ... Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest J. Dankiewicz and Others; foreign assistance act section 607foreign assisted projects denrWebJul 22, 2024 · The authors of the TTM trial have now come out with their subsequent study looking to assess the benefit of avoiding fever versus targeting a specific temperature in critically ill patients following cardiac arrest. Paper: Dankiewicz J et al. Hypothermia Versus Normothermia After Out-Of-Hospital Cardiac Arrest. NEJM 2024. PMID: 34133859 foreign assistance act of 1961 faaWebThe trial was stopped early for futility. At the time, 329 patients had been randomized (166 to hypothermia and 163 to normothermia). Among those patients, the percentage of children with a score ≥70 on the validated Vineland Adaptive Behavior Scale at 12 months follow-up was similar in the hypothermia and normothermia groups (36% vs. 39%, P ... foreign associateWebNov 9, 2024 · TTM at 33°C vs. normothermia 37.5°C : Survival with a CPC of 1 or 2 at 90 days: Significantly improved survival with a CPC of 1 or 2 in hypothermia group but no difference in overall mortality: Dankiewicz et al. [TTM2 trial] 1861: RCT: 2024: OHCA with a presumed cardiac cause: TTM at 33°C vs. targeted normothermia 37.5°C : Death from … foreign assistance dashboardWebThe ASEPSIS scores were higher in the hypothermia group than in the normothermia group (13±16 vs. 7±10, P = 0.002) ; these scores exceeded 20 in 32 percent of the former but only 6 percent of ... foreign assistance manual