Mapping genomic loci implicates genes
WebApr 7, 2024 · This large-scale, genome-wide association study compared the genomes (i.e., the DNA blueprint for the human body) of thousands of individuals in order to detect associations with a specific trait ... WebApr 8, 2024 · Mapping genomic loci implicates genes and synaptic biology in schizophrenia A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control…...
Mapping genomic loci implicates genes
Did you know?
WebAs existing genome-wide association studies (GWAS) have been conducted predominantly in individuals of European descent, the limited transferability of PRS reduces their clinical value in non-European populations, and may exacerbate healthcare disparities. WebMay 4, 2024 · Genome-wide polygenic score to predict chronic kidney disease across ancestries; Improving polygenic prediction in ancestrally diverse populations; Mapping genomic loci implicates genes and synaptic biology in schizophrenia; Cross-ethnicity/race generalization failure of behavioral prediction from resting-state functional connectivity
WebUsing fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes … Web15 hours ago · Baronas et al. paired human height GWASs with functional genome-wide screening of growth-plate chondrocytes. Targets were enriched in height heritability and genes critical for endochondral ossification. This study emphasizes that functional assays in relevant tissues can refine likely causal genes from GWASs and implicates new …
WebApr 12, 2024 · The genetic sub-study had a lower proportion of Black (30% in genetic vs 40% in CATIE overall) and other race (4% vs 6%) participants. ... Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2024 … WebSep 13, 2024 · Here, in 69,369 people with schizophrenia and 236,642 controls, we report common variant associations at 270 distinct loci. Using fine-mapping and functional …
WebMapping genomic loci implicates genes and synaptic biology in schizophrenia. Broad Institute Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature
WebMapping genomic loci implicates genes and synaptic biology in schizophrenia Author & abstract Download 5 Citations Related works & more Corrections Author Listed: Vassily … little arabia lebanese bakery and cuisineWebFDR<0.05hadstrongsupportfromfine-mapping:STAG1,whichis involvedincontrollingchromosomesegregationandregulatinggene expression;and … little arc academy west monroeWebUsing fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes … little archer \u0026 coWebOct 22, 2024 · Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. little arabia lebanese bakery \u0026 cuisineWebJan 8, 2024 · TGF-β and inflammatory pathways might be implicated, and there is evidence of genetic overlap for some cardiac phenotypes. Reduced absolute peak diastolic strain rates indicate increased myocardial stiffness and diastolic dysfunction, which increases risk of cardiac disease. little aquatics orlandoWebtitle = "Mapping genomic loci implicates genes and synaptic biology in schizophrenia", abstract = "Schizophrenia has a heritability of 60-80%1, much of which is attributable to … little arabia clevelandWebApr 8, 2024 · Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Mapping genomic loci implicates genes and synaptic biology in … little aquaman two