Farnesyl transferase antibody
WebAug 30, 2002 · Thus, there is an obvious need for new therapeutic strategies. 1 R115777, a nonpeptidomimetic farnesyl transferase inhibitor (FTI) initially developed to inhibit the growth of Ras transformed ... WebFarnesyltransferase (EC 2.5.1.58) is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid called a farnesyl group …
Farnesyl transferase antibody
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WebJun 10, 2024 · We observed significant differences in sensitivity to N-bisphosphonates and farnesyl-transferase inhibitors depending on KRAS mutational status and tissue of origin. ... blocking K-Ras dimerization and nanoclustering—either by genetic means or with specific antibodies—inhibits the efficacy of BRaf/CRaf heterodimerization and MAP kinase ... WebAnti-Farnesyl Antibody: Background Information: Protein isoprenylation is a post-translational modification that affects about 0.5% of cellular proteins and is essential for the biological activity of proteins. Two enzymes catalyze theattachment of two prenyl groups to the sulfhydryl group of carboxyl-terminal cysteine groups. Proteins which ...
WebThe best characterized among these prenyltransferases is the CAAX farnesyl transferase (2. 5. 1. 21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from … Webfarnesyl-transferase transfers a farnesyl, and when X is a leucine or isoleucine, the geranygeranyl-transferase I, a geranylgeranyl group. But despite its CKVL motif, RhoB was reported to be both ... polyclonal antibody against farnesyl cysteine methyl ester allow-ing prenylation analysis avoiding the metabolic labeling restric-
WebView all (2) Farnesyl antibodies. Catalog # PA1-12554. 100 µg. USD 489.00. Check your price & availability. Join Aspire™ for free antibodies. Quantity. Request bulk or custom … WebFarnesyl transferase is a zinc-dependent enzyme that catalyzes the attachment of a farnesyl lipid group to the sulfur atom of a cysteine residue of numerous proteins involved in cell signaling including the oncogenic H-Ras protein. Farnesyl transferase regulates the activation of Ras protein and consequently affects intracellular signal transduction, cell …
WebFNTA Antibody Summary. Immunogen. A portion of amino acids 150-250 of human farnesyltransferase was used as the immunogen. Specificity. …
WebJul 1, 2011 · Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused … maryland terrapins women\u0027s lacrosse scheduleWebView detailed Farnesyl Transferase antibody specifications by linking to the specific product blocks. Select appropriate Farnesyl Transferase antibodies for your research … husky crates spongeWebFarnesyl Transferase Antibodies. Anti-FTα Antibody (C-4) Anti-FTα Antibody (C-4): sc-373749 ... The purified farnesyl transferase is an ab heterodimer. The b subunit binds … husky creativeWebFarnesyl transferase is a zinc-dependent enzyme that catalyzes the attachment of a farnesyl lipid group to the sulfur atom of a cysteine residue of numerous proteins … husky corporation storageWebAnti-Farnesyl Antibody: Background Information: Protein isoprenylation is a post-translational modification that affects about 0.5% of cellular proteins and is essential for … husky couplings no hubWebLonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras and other farnesylated proteins. K- and N-Ras are also substrates of farnesyl transferase; however, upon treatment with FTIs, they are alternatively prenylated by geranylgeranyl transferase-1. Despite the failure to abrogate … husky cream cleanser msdsWebgsk2606414是一种选择性的perk抑制剂，ic50值为0.4 nm[1]。 prkr样内质网激酶或蛋白激酶r（pkr）样内质网激酶（perk），也被称为真核翻译起始因子2-α激酶3（eif2ak3），属于i型膜蛋白家族。perk位于内质网（er）中，被错误折叠蛋白引起的er应激所诱导。perk通过磷酸化真核翻译起始因子2（eif2）的α亚基，从而 ... husky c renewal form