WebDec 9, 2024 · Despite restoration of c-Myc expression fully restores glycolysis and in vitro proliferation of α5(IV) collagen-deficient luminal breast cancer cells, c-Myc expression only partially restores tumor growth in vivo, suggesting that other signaling pathways downstream of α5(IV) collagen, in synergy with the DDR1–p38 MAPK–c-Myc–glycolysis ... WebConclusion: TRIM66 was upregulated in human gliomas, where it promoted cell growth and chemoresistance. Our data also identified novel roles of TRIM66 in glioma progression. TRIM66 upregulates glucose uptake and mitochondrial function through the cMyc/GLUT3 signaling, which makes it a potential therapeutic target.
What you need to know about the oncogene c-MYC
WebThe transcription factor c-Myc plays critical roles in cancer development and progression through regulating expression of targeted genes. Lactate dehydrogenase A (LDHA), … WebJun 3, 2024 · C-myc/TSPEAR-AS2 Axis Facilitates Breast Cancer Growth and Metastasis in a GLUT1-Dependent Glycolysis Manner. Jian Xu, 1 Tao Li, 2 Yang Zhang, 1 Donghai Qiu, 3 Nan Chen, 4 Xupeng Chai, 5 PengLi, 6 and Jia Li 7 ... Aerobic glycolysis is a promising strategy for tumor therapy [9, 26, 27]. However, whether lncRNAs are contributed to the … hbf.com.au/member-perks
Regulatory mechanisms of lncRNAs in cancer glycolysis CMAR
WebNov 3, 2024 · By elevating the level of c-myc, HMGA1 was closely associated with the glycolysis gene signature and regulated glucose metabolism in gastric cancer cells (Cao et al. 2024). C-myc is a key transcription factor involved in the regulation of a variety of cellular functions, including cell growth, apoptosis, differentiation, cell motility and ... WebSep 5, 2024 · In addition, rescue experiments showed that LINC01123 functioned as an oncogene depending on miR-199a-5p and c-Myc. Since LINC01123 is upregulated in NSCLC, correlates with prognosis, and controls proliferation and aerobic glycolysis by a positive feedback loop with c-Myc, it is expected to be a potential biomarker and … WebJun 11, 2024 · NCAPD3 promoted aerobic glycolysis by regulating c-Myc and its downstream metabolism-related genes in CRC cells. c-Myc has been reported as a key regulator of glucose metabolism by directly binding to the promoters of GLUT1, HK2, ENO1, PKM2 and LDHA genes . To identify c-Myc was involved in NCAPD3-regulated aerobic … hbf cloverleaf