WebJul 25, 2003 · Bis(glutathionyl)spermine disulfide is a physiological substrate of recombinant trypanothione reductase, comparable to trypanothione and homotrypanothione disulfides. The broad substrate specificity of TcTryS could be exploited in the design of polyamine-based inhibitors of trypanothione metabolism. WebBis(glutathionyl)spermine. Molecular Formula C 30 H 56 N 10 O 10 S 2; Average mass 780.957 Da; Monoisotopic mass 780.362244 Da; ChemSpider ID 30791789
Bis(glutathionyl)spermine disulfide - Wikidata
WebTrypanothione is a unique low molecular weight peptide containing spermidine and glutathione skeletons in a cyclic structure. Chemically trypanothione is N 1,N 8-bis-(glutathionyl)spermidine (46), which is present in kinetoplastid flagellates [1].In trypanosomes, it plays an important role in maintaining intracellular thiol redox potentials, … WebBis (glutathionyl)spermine disulfide (Q27149614) chemical compound edit Statements instance of chemical compound 0 references type of chemical entity 0 references mass 778.347 dalton 1 reference chemical formula C₃₀H₅₄N₁₀O₁₀S₂ 1 reference canonical SMILES hotels near la porte county fair
Effect of N8-acetylspermidine deacetylase inhibition on the …
WebSeveral novel trypanothione analogues derived from spermine or other physiological polyamines have also been found in T. cruzi when supplemented with polyamines in the culture medium, among them homotrypanothione, N 1, N 12-bis(glutathionyl)spermine, N 1-glutathionyl-N 8-acetylspermidine, and N 1-glutathionyl-N 12-acetylspermine. … WebName Glutathione metabolism - Oryza sativa japonica (Japanese rice) (RAPDB) Class Metabolism; Metabolism of other amino acids BRITE hierarchy Pathway map dosa00480 Glutathione metabolism Ortholog table Module dosa_M00118 Glutathione biosynthesis, glutamate => glutathione [PATH: dosa00480] Other DBs GO: 0006749 Organism WebSep 1, 2003 · Trypanothione [N 1,N 8-bis(glutathionyl)spermidine] plays a central role in defence against oxidant damage, ribonucleotide metabolism and in resistance to certain drugs in trypanosomatids.In Crithidia fasciculata, synthesis of trypanothione involves sequential conjugation of two molecules of glutathione (GSH) to spermidine by two … lime in the coconut freestyle